From August 31 to September 2, 2016, clinicians and researchers from around the world met in Munich, Germany to present and discuss the newest findings on frontotemporal dementias at the 10th International Conference on Frontotemporal Dementias (ICFTD). The Penn FTD center was proud to participate!

The emphasis at the 2016 ICFTD was clear: biomarkers are essential for tracking disease progression in FTD and selecting patients for treatment trials.  Biomarkers, a shortened term for ‘biological markers’, refer to measurable indicators of a particular disease or physiological state. In FTD research, common biomarkers include brain imaging, cerebrospinal fluid (CSF), and genetics.

The Penn FTD Center’s Dr. David Irwin and Dr. Corey T. McMillan both spoke at the ICFTD and shared exciting new biomarker findings from our Center research. Dr. Irwin discussed how measurement of a protein called tau in CSF provides an in vivo marker of brain pathology in FTD. Dr. McMillan shared his work showing how information from the MOBP gene can relay information about certain types of FTD due to tau, including corticobasal syndrome (CBD) and progressive supranuclear palsy (PSP).

In addition, the Penn FTDC presented 18 scientific posters to share even more of our ongoing biomarker research. Clinical Research Coordinator Courtney Igne’s poster which highlighted the importance of caregivers’ attitudes towards biomarker research was included in a special Welcome Reception for FTD Caregivers.

The ICFTD and other scientific conferences allow the Penn FTDC to share our work and stay informed of exciting new clinical and research findings to better serve the FTD community.

Full List of Penn FTD Center posters and presentations at the 10th International Conference on Frontotemporal Dementias (ICFTD):


David Irwin, MD

Irwin, D.J., Lleó, A., McMillan, C.T., Cooper, F., Wolk, D, Shaw, L.M., Lee, E.B., Trojanowski, J.Q., Grossman, M.: Cerebrospinal fluid phosphorylated tau levels are associated with post-mortem tau inclusion burden in frontotemporal lobar degeneration

Corey McMillan, PhD

McMillan, C.T., Irwin, D., Byrne, M., Cooper, F., Firn, K., Jester, C., Suh, E., Van Deerlin, V., Trojanowski, J.Q., Grossman, M.: Converging Multimodal Evidence of Myelin Associated Proteins As Biomarkers in Four-Repeat Tauopathy


Baer, G.M., Byrne  M., Cooper, F., Suh, E., McCluskey, L., Elman, L., Wolk, D., Van Deerlin, V.M., Lee, V., Lee, E., Grossman, M., Trojanowski, J.Q., Irwin, D.J.: Sporadic FTLD TDP type C is a distinct clinicopathological entity from FTLD types A/B
Cousins, K.A.Q., Ash, S., Grossman, M.: Limited abstract word processing in behavioral variant frontotemporal degeneration
Igne, C.M., Massimo, L.M.,Firn, K., Halpin, A., York, C., Kofman, O.L., Langey, R., Grossman, M., McMillan, C.T.:Caregivers’ Attitudes Toward Family Participation in Frontotemporal Degeneration Biomarker Research
Irwin, D.J., Byrne, M., Wolk, D., Lee, E.B., Grossman, M., Trojanowski, J.Q.: Selective vulnerability of the locus coeruleus in frontotemporal lobar degeneration (FTLD) with tau pathology
Irwin, D.J., Lleó, A., McMillan, C.T., Cooper, F., Wolk, D, Shaw, L.M., Lee, E.B., Trojanowski, J.Q., Grossman, M.: Cerebrospinal fluid phosphorylated tau levels are associated with post-mortem tau inclusion burden in frontotemporal lobar degeneration
Jester III, C.A., Firn,K., Ternes, K., Shaw, L.M., Irwin, D.J., Weintraub, D., Grossman, M., McMillan, C.T.: Disease-Specific Relationship Between Cerebrospinal Fluid & Longitudinal Neuroimaging
Madhavan, R., Singanamalli, A., Mullick, R., Vaidya, V., Kodira, C., Van Deerlin, V., Grossman, M., David Irwin, D.J., McMillan, C.T.: Novel Connectome Approach Identifies Imaging-Genetic Associations in Sporadic Frontotemporal Degeneration
Massimo, L.M., Rennert, L., Xie, S. X., Van Deerlin, V.M.,Irwin, D.J., McMillan, C.T., Grossman, M.: Myelin Oligodendrocyte Basic Protein and Longitudinal Decline in Behavioral-Variant Frontotemporal Degeneration
Matallana, D., Ayala, P., Lopez, A., Zarante, I., Van Deerlin, V., McMillan, C.T., Irwin, D.J., McCarty Wood, E. Suh, E., Grossman, M., Rascovsky, K.: Colombian Familial Dementia with Frontotemporal Features Associated with a Presenilin-1 Mutation
McMillan, C. T., Schonhaut, D.,  Russell, D., Boxer, A., Litvan, I., Roberson, E., Nasrallah, I., Siderowf, A., Devous, M., Murray Grossman, M., Rabinovici, G.: Tau [18F]AV-1451 PET Uptake in Patients with Suspected 4-Repeat Tauopathy
Olm, C., McMillan, C.T., Irwin, D.J., Van Deerlin, V.M., Gee, J., Grossman, M.: Accelerated Structural White Matter Changes in Preclinical Progranulin Mutation Carriers
Phillips, J.S.,  Irwin, D.J., Rascovsky, K., Van Deerlin, V.M., Lee, V. M.-Y., Trojanowski, J.Q., McMillan, C.T., Grossman, M.: Cognitive and Behavioral Trajectory of Behavioral-Variant Frontotemporal Dementia Differs According to Underlying Pathology
Placek, K., Ternes, K., Massimo, L. M., Woo, J., Elman, L., McCluskey, L.
David Irwin, Murray Grossman, & Corey T. McMillan: Neuroanatomic and Neuropsychological Evidence of Cognitive Reserve in the ALS-FTD spectrum 
Reyes, P., Santamaría-Garcia, H., Uriza, F., Martinez, A., Iragorri, A., Matallana, D., Santacruz, J.M., Cano, C., Jester, C., Grossman M., McMillan C.T., Rascovsky, K.: Grey Matter Disease Distributions in a Colombian Cohort of Patients with
Frontotemporal Degeneration
Ternes, K., Kable, J., McGuire, J., Rascovsky, K., McMillan, C.T., Grossman, M.: Neural Correlates of Reversal Learning Deficits in Behavioral Variant Frontotemporal Degeneration
Vaddi, P., Wood, E.M., Van Deerlin, V.M., Irwin, D.J., Grossman, M., McMillan, C.T.: Estimation of Age of Onset in Presymptomatic Frontotemporal Dementia
White, N.C., Gervits, F., Ash, S., Coslett, H.B., Grossman, M., Hamilton, R.H.: Transcranial direct current stimulation as a potential therapy for symptoms of Primary Progressive Aphasia